A. No. App-V creates a set of virtual layers for the file system, registry, and other key environmental subsystems. When an application runs in App-V, it has no knowledge that it has been virtualized, so you can basically virtualize any application with App-V. The only major restrictions are that you can't (currently) virtualize 64-bit applications or device drivers. Pretty much any other application can be virtualized with App-V.
Related Reading:
Q. When should I use Microsoft Application Virtualization (App-V) as opposed to Microsoft Enterprise Desktop Virtualization (MED-V)?
Q. What is Microsoft Enterprise Desktop Virtualization (MED-V)?
App-V Security
App-V Streaming and Sequencing
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